ABSTRACT
OBJECTIVES: Vardenafil enhances dilatation of vascular smooth muscle and inhibits platelet aggregation. The purpose of this study was to evaluate the clinical effects of vardenafil and pentoxifylline administration in an experimental model of ischemic colitis. METHODS: Forty female Wistar albino rats weighing 250-300 g were randomized into five experimental groups (each with n = 8) as follows:1) a sham group subjected to a sham surgical procedure and administered only tap water; 2) a control group subjected to a standardized surgical procedure to induce ischemic colitis and administered only tap water; 3) and 4) treatment groups subjected to surgical induction of ischemic colitis followed by the postoperative administration of 5 mg/kg or 10 mg/kg vardenafil, respectively; and 5) a treatment group subjected to surgical induction of ischemic colitis followed by postoperative administration of pentoxifylline at 50 mg/kg/day per day as a single dose for a 3-day period. All animals were sacrificed at 72 h post-surgery and subjected to relaparotomy. We scored the macroscopically visible damage, measured the ischemic area and scored histopathology to determine the severity of ischemia. Tissue malondialdehyde levels were also quantified. RESULTS: The mean Gomella ischemic areas were 63.3 mm2 in the control group; 3.4 and 9.6 mm2 in the vardenafil 5 and vardenafil 10 groups, respectively; and 3.4 mm2 in the pentoxifylline group (p = 0.0001). The mean malondialdehyde values were 63.7 nmol/g in the control group; 25.3 and 25.6 nmol/g in the vardenafil 5 and vardenafil 10 groups, respectively; and 22.8 nmol/g in the pentoxifylline group (p = 0.0001). CONCLUSION: Our findings indicate that vardenafil and pentoxifylline are effective treatment options in an animal model of ischemic colitis. The positive clinical effects produced by these drugs are likely due to their influence on the hemodynamics associated ...
Subject(s)
Animals , Female , Colitis, Ischemic/drug therapy , Imidazoles/administration & dosage , Pentoxifylline/administration & dosage , /administration & dosage , Piperazines/administration & dosage , Colitis, Ischemic/pathology , Colitis, Ischemic/surgery , Colon/pathology , Colon/surgery , Disease Models, Animal , Hemodynamics/drug effects , Malondialdehyde/analysis , Random Allocation , Rats, Wistar , Reproducibility of Results , Sulfones/administration & dosage , Time Factors , Treatment Outcome , Triazines/administration & dosageABSTRACT
We report a 29 years old male, with a history of cocaine abuse and excessive alcohol intake, who was admitted to the hospital with an acute peritonitis. The patient was operated and multiple perforations of the cecum were found. A right hemicolectomy was performed and the pathological study of the surgical piece showed an ischemic colitis. A literature review reveals 22 reported cases of ischemic colitis associated to cocaine abuse
Subject(s)
Humans , Male , Adult , Cocaine/adverse effects , Colitis, Ischemic/chemically induced , Cocaine-Related Disorders/complications , Peritonitis , Cecum , Colectomy , Alcoholism , Anastomosis, Surgical , Cocaine/administration & dosage , Colitis, Ischemic/diagnosis , Colitis, Ischemic/pathology , Cocaine-Related DisordersABSTRACT
La colitis isquémica (CI) es la forma más común de injuria isquémica al tracto gastrointestinal, dada por una insuficiencia circulatoria del colon lo cual causa varios grados de necrosis tisular local, con o sin repercuciones sistémicas sin poder predecir el curso final de la enfermedad. Con el objeto de identificar los grupos de población susceptibles de sufrir esta patología, sus patrones de presentacion y sus complicaciones. Se realizó una revisión retrospectiva de quince casos (8 hombres, 7 mujeres), diagnosticados como CI por el Servicio de Cirugía y Endoscopia Colorrectal (SCECR) del Hospital Militar Central en un periodo comprendido entre enero de 1989 y enero del 2000. Se encontró que la hipertensión arterial y otras enfermedades cardiovasculares son los antecedentes patológicos asociados más frecuentes (73 por ciento). El tiempo transcurrido entre el inicio de los síntomas y el diagnóstico fue de 10,6 días (1-30). El examen de elección para el diagnóstico es la colonoscopia y el encontrar lesiones ulceradas circunferenciales son signos ominosos